Download Adipose Tissue and Adipokines in Health and Disease by Saverio Cinti MD (auth.), Giamila Fantuzzi PhD, Theodore PDF

By Saverio Cinti MD (auth.), Giamila Fantuzzi PhD, Theodore Mazzone MD (eds.)

ISBN-10: 1588297217

ISBN-13: 9781588297211

This publication offers a entire survey of adipose tissue, its physiological capabilities, and its position in illness. the amount spans the total diversity of adipose tissue reviews, from easy anatomical and physiological examine to epidemiology and scientific experiences. The authors are unusual researchers, clinicians and epidemiologists. they've got integrated groundbreaking fresh stories into conventional versions of adipose tissue homes.

Chapters on recognized homes of adipokines leptin and adiponectin are complemented via an creation to a unique view of adipose tissue as a dynamic organ that regulates systemic substrate availability and metabolism, in addition to various different discrete services. This novel notion is elevated.

Worldwide developments in weight problems are mentioned from an evolutionary standpoint and factors of the present weight problems epidemic are postulated. also, researchers and clinicians research the organization and strength function of adipose tissue in affliction mediation and provide epidemiological proof. This quantity concludes with a considerate and cutting edge dialogue of varied methods to inducing and maintaining weight reduction in overweight

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Extra info for Adipose Tissue and Adipokines in Health and Disease

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57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. Part I / Adipose Tissue: Structure and Function Cinti S, Zancanaro C, Sbarbati A, et al. Biol Cell 1989;67:359–362. Klaus S, Casteilla L, Bouillaud F, et al. Int J Biochem 1991;23:791–801. Ricquier D, Casteilla L, Bouillaud F. FASEB J 1991;5:2237–2242. Klaus, S. com, Austin, TX, 2001. Cannon B, Nedergaard J. Physiol Rev 2004;84:277–359. Lowell BB, S-Susulic V, Hamann A, Lawitts JA, et al. Nature 1993;366:740–742. Enerback S, Jacobsson A, Simpson EM, et al.

Compounds activating AMPK, such as metformin, may thus have an antilipolytic action (90). Last, evidence has been provided that serines 659 and 660 are also phosphorylated by cAMP-dependent protein kinase in vitro in rat adipocytes and that this phosphorylation could also stimulate lipolysis (91). Other pathways of phosphorylation have been described. Increased cAMP concentration can activate the mitogen-activated protein kinase/extracellular-regulated kinase (ERK) pathway (92,93). Activated ERK phosphorylates HSL at serine 600 and increases its activity (92).

63. 64. 65. 66. 67. 68. Part I / Adipose Tissue: Structure and Function Cinti S, Zancanaro C, Sbarbati A, et al. Biol Cell 1989;67:359–362. Klaus S, Casteilla L, Bouillaud F, et al. Int J Biochem 1991;23:791–801. Ricquier D, Casteilla L, Bouillaud F. FASEB J 1991;5:2237–2242. Klaus, S. com, Austin, TX, 2001. Cannon B, Nedergaard J. Physiol Rev 2004;84:277–359. Lowell BB, S-Susulic V, Hamann A, Lawitts JA, et al. Nature 1993;366:740–742. Enerback S, Jacobsson A, Simpson EM, et al. Nature 1997;387:90–94.

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