By Atta-ur- Rahman; M Iqbal Choudhary
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Extra info for Anti-obesity drug discovery and development Volume 1
Unlike other transcription factors, it does not contain homeodomains or zinc-fingers, but a distinct type of DNA-binding region including around 100 amino acids. The FOXO transcription factors in mammals are four: 1, 3, 4 and 6. FOX01 is involved in fundamental cellular processes such as apoptosis, responses to oxidative stress, cellular proliferation, cellular differentiation, and regulation of energy metabolism. On the other hand, oxidative stress and activation of the c-Jun N-terminal kinase (JNK) pathway induce the nucleocytoplasmic translocation of the pancreatic transcription factor PDX-1, which leads to pancreatic beta-cell dysfunction.
This is acchieved by binding to pancreatic lipase, thee main enzyyme that hhydrolyses trriglycerides . The long-term l effficacy of orrlistat (120 m mg three tim mes daily) fo or weight lo oss has been n demonstraated in seveeral clinical trials with following peeriods from 2 to 4 yearss . Additional evideence has beeen observed in several sy ystematic reeviews in ad dults  and a systeematic revieew with 2 sshort-term sttudies in ado olescents [29 98]. In n average, th he use of orliistart leads to o around 5 too 10 % weigght reductionn in 50-60 % of patientss after 12 months m of treeatment .
In this scenario, the biological impact of Mediterranean diet (MD) and regular physical exercise on cardiometabolic risk is outlined below. The Mediterranean Diet as a Model of Healthy Eating The Mediterranean diet (MD) has been widely considered as a model of healthy eating associated with a reduction in both total mortality and coronary heart disease (CHD) mortality [240, 241]. This is a current issue due to the PREDIMED Study An Approach to Obesity as a Cardiometabolic Anti-Obesity Drug Discovery and Development, Vol.