By Erik De Clercq
By means of concentrating on common molecular mechanisms of antiviral medications instead of cures for person viruses, this prepared reference offers the serious wisdom had to strengthen fullyyt novel therapeutics and to focus on new viruses.It starts off with a common dialogue of antiviral ideas, by means of a vast survey of recognized viral objectives, corresponding to opposite transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, in addition to their identified inhibitors. the ultimate part comprises numerous situations stories of modern profitable antiviral drug development.Edited by way of Erik de Clercq, the area authority on small molecule antiviral medications, who has constructed extra new antivirals than somebody else.
Read or Download Antiviral Drug Strategies (Methods and Principles in Medicinal Chemistry, Volume 50) PDF
Similar medical ebooks books
Emphasizes simple actual recommendations in bearing adoption, association, housing, lubrication, and sealants; exchange bearing kinds for particular initiatives; and specific recommendations to bearing layout difficulties. Textbook.
Written for drug builders instead of desktop scientists, this monograph adopts a scientific method of mining scientifi c facts assets, protecting all key steps in rational drug discovery, from compound screening to guide compound choice and custom-made medication. sincerely divided into 4 sections, the 1st half discusses the various facts resources to be had, either advertisement and non-commercial, whereas the subsequent part seems on the function and price of knowledge mining in drug discovery.
Attaining Cultural Competency: A Case-Based method of education healthiness execs offers the mandatory instruments to fulfill the ever-growing desire for culturally useful practitioners and trainees. Twenty-five self-study circumstances disguise a number of scientific issues, together with cardiovascular, pulmonary, neurology, oncology, hematology, immunology, and pediatric problems.
Smooth Pharmaceutics edited by way of Gilbert Banker and Christopher Rhodes has develop into a vintage within the box. it's renowned and has been good obtained on a global foundation, necessitating the booklet of this 5th version. the current editors took at the tough activity of following within the footsteps of the founding editors and their affiliates with a few trepidation.
Additional resources for Antiviral Drug Strategies (Methods and Principles in Medicinal Chemistry, Volume 50)
The farthest developed in the clinic (phase II) is a nonimmunosuppressive derivative of cyclosporin A, Debio-025 (structure as shown in Ref. ), a cyclophilin binding agent that has potent activity against both HCV  and HIV-1 . Debio-025 has shown potent anti-HCV activity in patients coinfected with HCV and HIV-1 . For the treatment of poliovirus, and other enterovirus, and rhinovirus infections, a large variety of antipicornavirus agents have been described , the last in the series being a protein 3A inhibitor, TTP-8307 .
De Clercq, E. (1980) Antiviral and antitumor activities of 5-substituted 20 - References 40 41 42 43 44 45 46 47 deoxyuridines. Methods and Findings in Experimental and Clinical Pharmacology, 2, 253–267. T. (1979) (E)-5-(2-Bromovinyl)-20 deoxyuridine: a potent and selective antiherpes agent. Proceedings of the National Academy of Sciences of the United States of America, 76, 2947–2951. De Clercq, E. (2004) Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster.
GS327073 is based upon the 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c] pyridine BPIP skeleton, which was akin to VP 32947  ﬁrst identiﬁed as a potent j15 j 1 Outlook of the Antiviral Drug Era 16 and selective inhibitor of the replication of pestiviruses such as BVDV . BPIP was from the start recognized as an inhibitor of RdRp, the ﬁnger domain of the enzyme being its target. Further chemical modiﬁcations of the BPIP skeleton led to the identiﬁcation of GS-327073 as a potent and selective NNRRI of the HCV RdRp, again with the ﬁnger domain being the target site .