By Graca Soveral, Soren Nielsen, Angela Casini
Since the invention of Aquaporin-1 (AQP1) as a water channel, many reports have printed the significance of aquaporins in mammalian body structure and pathophysiology in addition to plant and microbial biology. The reports have additionally proven aquaporins as power drug ambitions and goals for bettering crop properties.
Written through a global crew of participants on the vanguard of the sphere, Aquaporins in healthiness and illness: New Molecular pursuits for Drug Discovery provides the newest examine advances in aquaporins and different significant intrinsic protein (MIP) channels. the 1st portion of the booklet describes the overall suggestions of aquaporin channel functionality, genomic study, structure-function research of aquaporins and glycerol facilitators, and legislation by means of gating and trafficking, together with yeast aquaporin law and serve as. the second one part discusses the physiological and pathophysiological roles of aquaporins in people and microbes. the ultimate part covers the advance of inhibitors of aquaporin functionality. The book’s epilogue deals destiny views and instructions, customarily within the quarter of aquaporin-based diagnostics and therapeutics.
Stimulating destiny learn in this vital protein relatives, this booklet allows a paradigm shift within the figuring out and roles of aquaporin membrane proteins in all organic settings. It encourages scientists to enhance novel ways for the therapy of human illnesses in accordance with aquaporin functionality or dysfunction.
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Additional resources for Aquaporins in Health and Disease
Amino acids use standard abbreviations. X means any amino acid and question marks indicates uncertainty. Aquaporin Discovery in the Genomic Era ◾ 29 such as the two NPA boxes, but as more MIPs are sequenced, it is clear that this molecular signature of the MIP proteins is not totally universal (Ishibashi et al. 2011; Abascal et al. 2014; Khabudaev et al. 2014). csic. es/AQPs_chapter/: all the MIPs identified in UniprotKB, all metagenomic MIPs identified in UniMES, maximum percentage of sequence identity for each of the metagenomic MIPs compared to known MIPs, multiple sequence alignment of 730 metagenomic MIPs and 1,489 MIPs from Abascal et al.
5:7789. M. L. Weissberg. 1998. The aquaporins. A family of water channel proteins. Int. J. Biochem. Cell Biol. 30:169–172. H. and U. Johanson. 2008. Unexpected complexity of the Aquaporin gene family in the moss Physcomitrella patens. BMC Plant Biol. 8:1–15. H. and U. Johanson. 2010. Phylogeny of major intrinsic proteins. In MIPs and Their Role in the Exchange of Metalloids, eds. P. P. Bienert, pp. 19–31. New York: Springer. N. and J. Cerda. 2015. Evolution and functional diversity of aquaporins.
Kondo, S. Hara and Y. Morishita. 2011. The evolutionary aspects of aquaporin family. Am. J. Physiol. Reg. Integr. Comp. Physiol. 300:R566–R576. Johanson, U. and S. Gustavsson. 2002. A new subfamily of major intrinsic proteins in plants. Mol. Biol. Evol. 19:456–461. , M. Karlsson, I. Johansson, S. Gustavsson, S. Sjövall, L. R. Weig and P. Kjellbom. 2001. The complete set of genes encoding major intrinsic proteins in Arabidopsis provides a framework for a new nomenclature for major intrinsic proteins in plants.