Download Arenaviruses: Genes, Proteins, and Expression by M. B. A. Oldstone (auth.), Michael B. A. Oldstone M.D. PDF

By M. B. A. Oldstone (auth.), Michael B. A. Oldstone M.D. (eds.)

ISBN-10: 3642716857

ISBN-13: 9783642716850

M. B. A. OLDSTONE Viruses are in general studied both simply because they reason major human, animal or plant illness or for his or her application as fabrics to probe a uncomplicated phenomenon in biology, chemistry, genetics or molecular biology. Arenaviruses are surprisingly fascinating in that they occupy either one of those different types. Arenaviruses reason serious human illnesses recognized essentially because the hemor­ rhagic fevers happening in South and Latin the US (Bolivia: Machupo virus and Argentina: Junin virus) and in Africa (Lassa virus). simply because such viruses produce profound incapacity and should kill the people they infect, they're a resource of monetary problem within the international locations the place they're primary. extra, they supply new difficulties for overall healthiness care group of workers as a result of the narrowing of the realm as viewers from many nations more and more trip to and from those endemic components. moreover, lymphocytic choriomeningitis virus (LCMV) can infect people all over the world, even though the disorder is in most cases much less disabling than these elicited via different arenaviruses. but LCMV is probably going of larger situation to non-arena-virologists and experimentalists utilizing tissue tradition or animals, i. e. , employees in molecular biology, melanoma examine, virology, immunobiology, and so on. , simply because basic showing cultured cells or tissues and animals used for learn can be over and over contaminated with LCMV with out manifesting scientific sickness or cytopathology and transmit that an infection to laboratory staff (reviewed OWSTONE and PETERS 1978). for instance, HINMAN et al.

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Example text

As discussed in more detail in Sect. 4, GPC is the precursor of the structural glycoproteins. Intracellular GPC is an oligomannosyl rich glycopeptide which is processed posttranslationally by carbohydrate trimming and proteolytic cleavage prior to virus release (Fig. 2). Pulse-chase experiments (HARNISH et al. 1981; DIMOCK et al. 1982) have shown that the synthesis of GPC correlates closely with production of infectious virions. As GPC synthesis and consequent expression of viral glycoprotein at the plasma membrane increase, so does virus production.

Moreover by surface iodination of LCMV (BUCHMEIER and OLDSTONE 1979) it was shown that GP1 was the predominant virus-specific molecule accessible to lactoperoxidase-catalyzed iodination on the plasma membranes of infected cells and on the envelope. The macromolecular arrangement of glycoproteins in the membrane has been studied by BRUNS and LEHMANN-GRUBE (1983). Based primarily on cross-linking and nearest neighbor analyses, they suggest that the glycoprotein spike of LCMV consists of a complex of 1 gp 35 molecule linked to either three gp 44 molecules or one gp 44 and one gp 85 molecule.

1977), Lassa fever (CLEOG and LLOYD 1983), and Machupo (LUKASHEVICH and LEMESHKO 1985) viruses. As discussed in more detail in Sect. 4, GPC is the precursor of the structural glycoproteins. Intracellular GPC is an oligomannosyl rich glycopeptide which is processed posttranslationally by carbohydrate trimming and proteolytic cleavage prior to virus release (Fig. 2). Pulse-chase experiments (HARNISH et al. 1981; DIMOCK et al. 1982) have shown that the synthesis of GPC correlates closely with production of infectious virions.

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